041 Cognitive and neuropsychiatric effects of noradrenergic treatment in Alzheimer’s disease: systematic review and meta-analysis
نویسندگان
چکیده
Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease. This results a low-noradrenergic state some patients, which contributes to cognitive and neuropsychi- atric symptoms. We aimed assess efficacy noradrenergic drugs for improving these Methods The MEDLINE, Embase, ClinicalTrials.gov databases were searched from 1980 December 2021. generated pooled estimates using random effects meta-analyses. Results 19 randomised controlled trials, six studies ‘good’ quality, with seven ‘fair’ ‘poor’, included 1811 patients. Meta-analysis 10 showed small, significant positive effect on patients’ global cognition, as measured MMSE or ADAS-Cog compared placebo (SMD:0.14, 95%CI:0.03 0.25, p=0.01; I2=0%). No was seen measures attention (SMD:0.01, 95%CI:-0.17 0.19, p=0.91; I2=0). apathy meta-analysis eight trials detected large (SMD:0.45, 95%CI:0.16 0.73, p=0.002; I2=58%), although limited by potentially substantial heterogeneity. Discussion Drug repurposing established drugs, may offer safe effective treatment disease, both cognition apathy. However, there are number factors that should be considered before design much needed future clinical trials. Including, targeting correct patient sub-groups medications, at optimal dose, possibly combination other treatments, order maximise therapeutic effect.
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery, and Psychiatry
سال: 2022
ISSN: ['0022-3050', '1468-330X']
DOI: https://doi.org/10.1136/jnnp-2022-abn2.85